Who gets non-sexually acquired human papillomavirus infections? Transmission of non-sexually acquired HPV occurs when infected skin or skin squames are in direct contact with broken or macerated skin. HPV infections can be sexually transmitted or non-sexually acquired this review focuses on the latter. Each type is associated with infection at a particular anatomic site and clinical morphology. Human papillomavirus (HPV) is a small double-stranded DNA virus which has been classified into over 200 types based on genome sequencing. What is a non-sexually acquired human papillomavirus infection?